In collaboration with the Maria Falkenberg lab and several other labs, we have developed a new tool, MitoSAlt, for detecting structural alterations in mitochondrial DNA using high throughput sequencing. MitoSAlt is currently the only method that can discriminate between deletions and duplications in mtDNA using short read sequencing.
The paper is finally out in PLoS Genetics.
Congratulations to Swaraj, Xie, Jennifer and everyone else!
Beautiful Christmas decorations by Ari and Kerryn:
Christmas and farewell dinner for Jimmy and Susanne.
Congratulations to Jimmy on his paper on selective pressure acting on tumor neoantigens and the importance of accurate background mutation models in this context.
Collaboration with the Miller lab at CRUK Cambridge Institute, University of Cambridge.
Read Jimmy’s blog post.
Visiting the EMBL Cancer Genomics conference in Heidelberg.
We have a new paper out where we dig deeper into the mutational signature of ultraviolet light, including longer contextual patterns that may be informative of mutation rate. Congratulations to Markus and his coauthors Kerryn and Martin.
Once again we paid a visit to the EACR Cancer Genomics conference in Cambridge, UK.
Congratulations to Martin for successfully completing his PhD halftime seminar!
Congratulations to Markus for successfully completing his PhD halftime seminar!
Our paper on the mechanistic origin of recurrent promoter mutations in skin cancers is finally out in PLOS Genetics! Congratulations to Kerryn, Martin and all coauthors, who worked hard on this for a long time.